Zhen Du

 duzhen@him.cas.cn

Biography

Dr. Zhen Du received her PhD in Bioinorganic Chemistry from the Institute of High Energy Physics, Chinese Academy of Sciences in 2019. In the same year, she began her postdoctoral research at the Institute of Translational Medicine, Zhejiang University. In 2021, she joined the Hangzhou Institute of Medicine, Chinese Academy of Sciences.

Research Interests

Her research Interests focuses on innovative approaches in functional nucleic acid drug delivery and cancer therapy.

I: Engineering mRNA coding therapeutic proteins for tumor immunotherapy.

II: Design and delivery of intelligent, responsive nucleic acid drugs.

III: Application of nucleic acid drugs in radiotherapy.

Selected Publications

Du Z.*, Wang X., Zhang, X., Gu, Z., Fu X., Gan S., Fu T., Xie S.*, Tan W. X-Ray-triggered Carbon Monoxide and Manganese Dioxide Generation based on Scintillating Nanoparticles for Cascade Cancer Radiosensitization. Angewandte Chemie International Edition.2023, 62:e202302525. https://doi.org/10.1002/anie.202302525

Du Z., Zhang X., Guo Z., Xie J., Dong X., Zhu S., Du J., Gu Z.*, Zhao Y.X-Ray-Controlled Generation of Peroxynitrite Based on Nanosized LiLuF4:Ce3+ Scintillators and their Applications for Radiosensitization.Advanced Materials, 2018,30:1804046. https://doi.org/10.1002/adma.201804046

Du Z., Qi Y., He J., Zhong D., Zhou M.*, Recent Advances in Applications of Nanoparticles in SERS in vivo Imaging. Wiley Interdisciplinary Reviews: Nanomedicine, 2021, 13, e1672.

https://doi.org/10.1002/wnan.1672

Du Z., Dou R., Zu M., Liu X., Yin W., Zhao Y., Chen J.*, Yan L.*, Gu Z.* Nitric Oxide-Generating L-Cysteine-Grafted Graphene Film as a Blood-contacting Biomaterial. Biomaterials Science, 2016, 4:938.

https://doi.org/10.1039/C6BM00074F

Zheng Y., Wei Y., Yang Y., Wen X., Yang C., Xiao Y., Du Z.*, Liu X.*, Development of Manganese Carbonyl Loaded Upconversion Nanoparticles for Near-Infrared-Triggered Carbon Monoxide and Mn2+ Delivery. Advanced NanoBiomed Research, 2024, 2300171.

https://doi.org/10.1002/anbr.202300171

Shi, M., Du, Z.*, Qi, Y., Li W, Hu H, Lin X, Wang S*, Tang Z*, Zhou M.*, Wound Microenvironment-Responsive Glucose Consumption and Hydrogen Peroxide Generation Synergistic with Antibiotics for Diabetic Wounds Healing. Theranostics, 2021.

https://doi.org/

Pan, X.#, Qi, Y. #, Du, Z.*, He, J., Yao, S., Lu, W., Ding, K.*, Zhou, M.*, Zinc Oxide Nanosphere for Hydrogen Sulfide Scavenging and Ferroptosis of Colorectal Cancer. Journal of Nanobiotechnology, 2021.

https://doi.org/10.1186/s12951-021-01069-y

Contacts

E-mail: duzhen@him.cas.cn

Office Room: 4-204

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Dongfang Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000