Biography

Dr.Wei Zhu obtained his PhD degree from Zhejiang University in 2016. After graduating, he continued his work at Zhejiang University as postdoc researcher until 2018. From 2018 to 2020, he studied at the University of Florida as a postdoc. In 2021, he joined the Hangzhou Institute of Medicine, Chinese Academy of Sciences as an assistant professor.

Research Interests

Research Interest I: Multiomics for Medicinal Plants under Abiotic Stress

We have developed an active-enzyme induction method to enhance the levels of active ingredients in medicinal plants such as Morus, Mahonia,Ginkgo, Lonicera, Taxus, Catharanthus, and Clematis. Our research is focused on elucidating the underlying mechanism of this induction and revealing the biosynthetic pathways of the active ingredients using mutiomics techniques such as proteomics, metabolomics, transcriptomics.

Research Interest II: Clinical Systems Biology

In this research area, we focus on the underlying mechanism of action of traditional Chinese medicine in disease prevention and treatment as well as related biomarkers by integrating systems biology approaches and large-scele medical data. It will contribute to the early disease diagnosis and facilitate the development of new products in traditional Chinese medicine.

Selected Publications

Please list your selected publications.

(1)Proteomic analysis of Lonicera japonica Thunb. immature flower buds using combinatorial peptide ligand libraries and polyethylene glycol fractionation.

Wei Zhu, Xiaobao Xu, Jingkui Tian, Lin Zhang*, Setsuko Komatsu*. Journal of Proteome Research, 2016, 15, 166-181.

(2) Combined ultraviolet and darkness regulation of medicinal metabolites in Mahonia bealei revealed by proteomics and metabolomics.

Wei Zhu#, Haote Han#, Amin Liu, Qijie Guan, Jianing Kang, Lisa David, Craig Dufresne, Sixue Chen,* Jingkui Tian*.Journal of Proteomics, 2021, 233, 104081

(3) Proteomic analysis of Morus leaf epidermis indicates the roles of photosystem and ROS in UV-B response.
Li Yaohan,Haodong Xia,Shawky Eman,Liu Shengzhi,Tao Minglei,Liu Amin, Sulaiman Kaisa,Tian Jingkui, Zhu Wei*. Industrial Crops & Products, 2022, 188, 115683.

(4) Integrating plasma metabolomics and proteomics reveals novel molecular insights and biomarker panels for cholelithiasis.

Jiahui Gong#, Yue Feng, Ying Mei, Shuwen Han, Xu Sun, Pingping Niu, Jingkui Tian, Qiang Yan*, Hanbing Li*, Wei Zhu*. Journal of Pharmaceutical and Biomedical Analysis2024, 238, 115806.

(5) Proteomic and metabolomic characterization of bone, liver, and lung metastases in breast cancer patient plasma.

Ye Hui, Shen Xiabo, Li Yaohan, Zou Weibin, Feng Yue, Wang Xiaojia, Tian Jingkui, Shao Xiying*, Tao Yi*, Zhu Wei*. Proteomics-Clinical Applications,2024, 2300136.

Contacts

E-mail: zhuwei@him.cas.cn

Hangzhou Institute of Medicine

Chinese Academy of Sciences

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000