Biography

Dr. Jie Song is a researcher at the Hangzhou Institute of Medicine, Chinese Academy of Sciences, Professor at Shanghai Jiao Tong University, and a recipient of the National Overseas High Level Talent Youth Program (2016). He is also a recipient of the Outstanding Youth Fund of the Natural Science Foundation (2018).

Research Interests

The main research directions of the research group are DNA nanotechnology and molecular communication and information storage, intelligent drug delivery systems and gene therapy, as well as the development and application of intelligent diagnostic and therapeutic instruments. The research group has published over 100 articles, including top international academic journals such as Science, Nature, Cell, Nature Nano, Nature Chemistry, Nature Communication, PNAS, JACS, etc.

Selected Publications

• Rui Ye, Ziyu Zhu, Tianyi Gu, Dengjie Cao, Kai Jiang, Qiang Dai, Kuoran Xing, Yifan Jiang, Siyi Zhou, Ping Cai, David Tai Leong*, Mengfei Yu*, Jie Song*. Neutrophil extracellular traps-inspired DNA hydrogel for wound hemostatic adjuvant. Nature Communications. 2024, 15, 5557. https://doi.org/10.1038/s41467-024-49933-3

• Zhijin Tian, Dandan Shao, Linlin Tang, Zhen Li, Qian Chen, Yongxiu Song, Tao Li, Friedrich C. Simmel, Jie Song*. Circular single-stranded DNA as a programmable vector for gene regulation in cell-free protein expression systems. Nature Communications. 2024,15, 4635. https://doi.org/10.1038/s41467-024-49021-6

• Linlin Tang, Zhijin Tian, Jin Cheng, Yijing Zhang, Yongxiu Song, Yan Liu, Jinghao Wang, Pengfei Zhang, Yonggang Ke*, Friedrich C. Simmel*, Jie Song*. Circular single-stranded DNA as switchable vector for gene expression in mammalian cells.Nature Communications. 2023, 14, 6665. https://doi.org/10.1038/s41467-023-42437-6

• Chao Gao, Jinge Gu, Hong Zhang, Kai Jiang, Linlin Tang, Ren Liu, Li Zhang, Pengfei Zhang, Cong Liu*, Bin Dai*, Jie Song*.  Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus. Cell Reports.2022,40(3). https://doi.org/10.1016/j.celrep.2022.111086

• Yufeng Pei, Tianyuan Bian, Yonglin Liu, Yan Liu, Yujie Xie, Jie Song*.Single-molecule Resettable DNA Computing via Magnetic Tweezers. Nano Letters. 2022, 22(7): 3003–3010. https://doi.org/10.1021/acs.nanolett.2c00183

• Sisi Fan, Bin Ji, Yan Liu, Kexuan Zou, Zhijin Tian, Bin Dai, Daxiang Cui, Pengfei Zhang,  Yonggang Ke, Jie Song*, Spatiotemporal Control of Molecular Cascade Reactions by a Reconfigurable DNA Origami Domino Array. Angewandte Chemie International Edition. 2022; 61: e202116324. https://doi.org/10.1002/anie.202003823

• Sisi Fan, Dongwang Wang, Jin Cheng, Yan Liu, Tao Luo, Daxiang Cui, Yonggang Ke,Jie Song*. Information Coding in Reconfigurable DNA Origami Domino Array. Angewandte Chemie International Edition. 2020,59: 12991– 12997. https://doi.org/10.1002/anie.202003823

• Sisi Fan, Jin Cheng, Yan Liu, Dongfang Wang*, Tao Luo, Bin Dai, Chuan Zhang, Daxiang Cui, Yonggang Ke*, Jie Song*. Proximity-Induced Pattern Operations in Reconfigurable DNA Origami Domino Array. Journal of the American Chemical Society. 2020. 142(34): 14566–14573. https://doi.org/10.1021/jacs.0c06061

• Yan Liu, Jin Cheng, Sisi Fan, Huan Ge, Tao Luo, Linlin Tang, Bin Ji, Chuan Zhang, Daxiang Cui, Yonggang Ke, Jie Song*. Modular Reconfigurable DNA Origami: from 2D to 3D. Angewandte Chemie International Edition. 2020, 59: 23277– 2328. https://doi.org/10.1002/ani.202010433

• Jie Song*, Zhe Li, Pengfei Wang, Travis Meyer, Chengde Mao*, Yongkang Ke*: Reconfiguration of DNA Molecular Arrays Driven by Information Relay. Science. 2017,357(6349): eaan3377. https://doi.org/10.1126/science.aan3377

Contacts

E-mail: songjie@him.cas.cn

Office Room: 4-303

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000