Xiaohong Fang received her B. S. degree in chemistry from Wuhan University in 1990 and obtained her M. S. and Ph. D. degrees from Peking University in 1993 and 1996, respectively. She went to University of Waterloo, Canada, in 1997 and did a one-year postdoctoral work there. During 1998-2001, she worked as a research associate at Chemistry Department and Center for Research at Bio/nano Interface at University of Florida, USA. She was appointed as a chemistry professor in the Institute of Chemistry in December of 2001. Since January 2022, she has held the positions of Deputy Director and researcher at the Hangzhou Institute of Medical Research, Chinese Academy of Sciences.

Research Interests

Our research focuses on biomarker detection and cancer therapy. The available tumor markers, such as proteins and miRNAs, have been known to help early-stage diagnosis of diseases. A novel tumor marker related to cancer cell proliferation and recurrence are meaningful to personal cancer therapy. We developed a lot of imaging methods to identify and recognize tumor, especially, we have got a lot of information about tumor from extracellular vesicles (EVs) released by various cell types. Meanwhile, we aim to find out the mechanism of drug resistance of tumor and carry out many methods to treat tumor by targeting the biomarkers, such as protein degradation and genetic engineering.

Selected Publications

1. “Optical Imaging of Single Extracellular Vesicles: Recent Progress and Prospects”. Bochen Ma, Li Li, Yuting Bao, Liang Yuan, Songlin Liu, Liqing Qi, Sihui Tong, Yating Xiao, Lubin Qi, Xiaohong Fang*, and Yifei Jiang*. Chemical & Biomedical Imaging,  2, 1, 27-46, 2024. (Review)

2. Monodispersed and Monofunctionalized DNA-Caged Au Nano-Clusters with Enhanced Optical Properties for STED Imaging. Liqing Qi, Yating Xiao, Xiaoyi Fu, Hongwei Yang, Le Fang, Rui Xu, Jiantao Ping, Da Han, Yifei Jiang,* and Xiaohong Fang*. Small, 2400238, 2024. (IF=13.3)

3. Ultrasensitive Point-of-Care Detection of Protein Markers Using an Aptamer-CRISPR/Cas12a-Regulated Liquid Crystal Sensor (ALICS). Lubin Qi, Jie Liu, Songlin Liu, Yang Liu, Yating Xiao, Zhen Zhang, Wei Zhou, Yifei Jiang*, and Xiaohong Fang*. Analytical Chemistry, 96, 2, 866-875,2024. (IF=7.4)

4. RuCu Nanosheets with Ultrahigh Nanozyme Activity for Chemodynamic Therapy. Jian Yang, Le Fang, Ruibin Jiang, Lubin Qi, Yating Xiao, Wenxi Wang, Ismail Ismail, 

8. Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy. Yong-Dan Zhao, Hong-Wei An, Muhetaerjiang Mamuti, Xiang-Zhong Zeng, Rui Zheng, Jia Yang, Wei Zhou, Yuxin Liang, Gege Qin, Da-Yong Hou, Xiaolong Liu, Hao Wang*, Yuliang Zhao*, Xiaohong Fang*. Advanced Materials, 2211332, 2023. (IF=29.4)

Contacts

E-mail: xfang@iccas.ac.cn

Website:

Office Room: 1-405

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000