Biography

Dr. Hao Chang obtained his Ph.D. degree in Polymer Materials (2015) from Zhejiang University, China. Since 2016, he has successively worked as a research fellow at the School of Chemical and Biomedical Engineering, Nanyang Technological University (Singapore), and the Department of Biomedical Engineering, City University of Hong Kong. Currently, Dr. Chang holds a position as a researcher (principal investigator) at the Hangzhou Institute of Medicine, Chinese Academy of Sciences, China. He has published over 40 peer-reviewed papers in top journals, including Nature Biomedical Engineering, Advanced Materials, Biomaterials, Small, and Advanced Healthcare Materials, et al.

Research Interests

His research interests include biomaterials, drug delivery, micro-/nanotechnologies, regenerative medicine, biomedical engineering. Currently, his research focuses on engineering advanced microneedle-based drug delivery systems and devices for diverse biomedical applications, such as vaccination, tumor immunotherapies, cell therapies and point-of-care diagnosis, et al.

Selected Publications

1. P. Zhao, Z. Li, Z. Ling, Y. Zheng, H. Chang*, Efficient loading and sustained delivery of methotrexate using a tip-swellable microneedle array patch for psoriasis treatment, ACS Biomater. Sci. Eng., 2024,10(2): 921-931.
2. Z. Li, P. Zhao, Z. Ling, Y. Zheng, F. Qu, H. Chang*, An ultraswelling microneedle device for facile and efficient drug loading and transdermal delivery, Adv. Healthc. Mater., 2024,13(2): e2302406.
3. Z. Ling, Y. Zheng, Z. Li, P. Zhao, H. Chang*, Self-Healing Porous Microneedles Fabricated Via Cryogenic Micromoulding and Phase Separation for Efficient Loading and Sustained Delivery of Diverse Therapeutics, Small, 2023, e2307523.
4. H. Chang*, X. Wen, Z. Li, Z. Ling, Y. Zheng, C. Xu*, Co-delivery of dendritic cell vaccine and anti-PD-1 antibody with cryomicroneedles for combinational immunotherapy, Bioeng. Transl. Med., 2023, 8(5), e10457.
5. H. Chang, S.W.T. Chew, M. Zheng, D.C.S. Lio, C. Wiraja, Y. Mei, X. Ning, M. Cui, A. Than, P. Shi, D. Wang, K. Pu, P. Chen, H. Liu, C. Xu*, Cryomicroneedles for transdermal cell delivery, Nat. Biomed. Eng., 2021, 5(9): 1008-1018.
6. H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni, R. Kang, J. Tian, D.P. Khanh, L. Liu, P. Chen*, C. Xu*, A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis, Adv. Mater., 2017, 29(37): 1702243.

Contacts

E-mail: changhao@him.cas.cn

Website: https://scholar.google.com/citations?user=O4t517gAAAAJ&hl=en

Office Room: 1-806 (Heda Pharmaceutical Valley Stage 4)

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310018