Biography

Xiaohong Fang received her B. S. degree in chemistry from Wuhan University in 1990 and obtained her M. S. and Ph. D. degrees from Peking University in 1993 and 1996, respectively. She went to University of Waterloo, Canada, in 1997 and did a one-year postdoctoral work there. During 1998-2001, she worked as a research associate at Chemistry Department in University of Florida, USA. She was appointed as a professor in the Institute of Chemistry, Chinese Academy of Sciences in December of 2001, and worked there since then. InAugust 2020, she was appointed as the Executive Dean of Molecular Medicine Department at the Hangzhou Institute of Advanced Studies, University of Chinese Academy of Sciences, and became a professor at the Hangzhou Institute of Medicine, Chinese Academy of Sciences (HIMCAS). In July 2023, she was appointed as the Deputy Director of HIMCAS.She has served as an Associate Editor for Analytical Chemistry since 2016 and editorial board members for many International academic journals,e.g. National Science Review and International Journal of Nanomedicine. She is currently an associate member of IUPAC Chemistry and Human Health Division.

Research Interests

Fang group’s major research interests include the development of highly sensitive biomedical methods at the single molecule level, investigation of single proteinmolecules related to cell signal transductionin living cells, identification of tumor biomarkers for molecular diagnosis and treatment. She has published over 240 papers in prestigious international academic journals such as JACS, PNAS,Nature Commun.,Nature Biotech. , etc.

Selected Publications

• “Signaling Molecule from Intratumor Bacteria Promotes Trastuzumab Resistance in Breast Cancer Cells”. Gege Qina, Xiying Shao, Xiaolong Liu, Jiachao Xu, Xiaojia Wang, Wenxi Wang, Lu Gao, Yuxin Liang, Lina Xie, Dan Su, Hongwei Yang,Wei Zhou*, and Xiaohong Fang,* Proceedings of the National Academy of Sciences of the United States of America. 122(2), e2421710122, 2025.

• Single-Molecule Liquid Biopsy Detects Low- and High-Abundance Protein Markers Simultaneously for Pancreatic Cancer Diagnosis，Xinjian Wang, Yudong Che, Songlin Liu, Bochen Ma, Yijun Liu1, Jiao Lei，Liang Yuan, Yiwen Zhou, Jieer Ying, Yimin Zhang, Chen Tian, Zhu Tao, Lubin Qi*, Yifei Jiang*, Xiaohong Fang* Anal. Chem., 97, 8385−8393, 2025

• Self-stacked small molecules for ultrasensitive, substrate-free Raman imaging in vivo. Shuai Gao , Yongming Zhang, Kai Cui , Sihang Zhang , Yuanyuan Qiu, Yunhui Liao , Haoze Wang, Sheng Yu , Liyang Ma, Hongzhuan Chen, Minbiao Ji, Xiaohong Fang*, Wei Lu* , Zeyu Xiao*,Nature biotechnology, doi: 10.1038/s41587-024-02342-9, 2024.

• Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions, Jing Wang , Zhengyang An, Zhongsheng Wu, Wei Zhou , Pengyu Sun, Piyu Wu , Song Dang, Rui Xue , Xue Bai, Yongtao Du , Rongmei Chen, Wenxu Wang, Pei Huang, Sin Man Lam, Youwei Ai , Suling Liu , Guanghou Shui , Zhe Zhang, Zheng Liu , Jianyong Huang , Xiaohong Fang*, Kangmin He*, Molecular Cell, 84(22), 4401-4418, 2024.

• Cell dehydration enables massive production of engineered membrane vesicles with therapeutic functions，Jie Liu，Tingting Shen，Yu Zhang，Xiaojian Wei，Yuting Bao，Rui Ai，Shaoju Gan, Dachi Wang, Xin Lai, Libo Zhao, Wei Zhou, Xiaohong Fang, J. Extracell. Vesicles, 13:e12483, 2024

• Ultra-sensitive Detection of Cancer Biomarkers using Photonic-crystal-enhanced Single-molecule Imaging,: Liu, Songlin; Ma, Bochen; Qi, Liqing; Ping, Jiantao; Che, YuDong; Zhang, YiMin; Su, Meng; Song, Yanlin; Qi, Lubin* ; Jiang, Yifei*; Fang, Xiaohong*, Anal. Chem. 96(33), 13719-13726,2024.

• “Optical Imaging of Single Extracellular Vesicles: Recent Progress and Prospects”. Bochen Ma, Li Li, Yuting Bao, Liang Yuan, Songlin Liu, Liqing Qi, Sihui Tong, Yating Xiao, Lubin Qi, Xiaohong Fang*, and Yifei Jiang*. Chemical & Biomedical Imaging,  2, 1, 27-46, 2024.

• Monodispersed and Monofunctionalized DNA-Caged Au Nano-Clusters with Enhanced Optical Properties for STED Imaging. Liqing Qi, Yating Xiao, Xiaoyi Fu, Hongwei Yang, Le Fang, Rui Xu, Jiantao Ping, Da Han, Yifei Jiang,* and Xiaohong Fang*. Small, 2400238, 2024.

•  Ultrasensitive Point-of-Care Detection of Protein Markers Using an Aptamer-CRISPR/Cas12a-Regulated Liquid Crystal Sensor (ALICS). Lubin Qi, Jie Liu, Songlin Liu, Yang Liu, Yating Xiao, Zhen Zhang, Wei Zhou, Yifei Jiang*, and Xiaohong Fang*. Analytical Chemistry, 96, 2, 866-875,2024.

• RuCu Nanosheets with Ultrahigh Nanozyme Activity for Chemodynamic Therapy. Jian Yang, Le Fang, Ruibin Jiang, Lubin Qi, Yating Xiao, Wenxi Wang, Ismail Ismail, and Xiaohong Fang*. Advanced Healthcare Materials, 2300490, 2024.

• Mitochondrial Protease Targeting Chimeras for Mitochondrial Matrix Protein Degradation. Dachi Wang, Wenxi Wang, Le Fang, Lubin Qi, Yuchao Zhang, Jie Liu, Yuxin Liang, Hongwei Yang, Mengjie Wang, Xiaojian Wei, Ruibin Jiang, Yuan Liu, Wei Zhou*, and Xiaohong Fang*. Journal of the American Chemical Society, 145, 23, 12861-12869, 2023.

• The RNA-binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung Cancer. Wei Zhou, Wenxi Wang, Yuxin Liang, Ruibing Jiang, Fensheng Qiu, Xiying Shao, Yang Liu, Le Fang, Maowei Ni, Chenhuan Yu, Yue Zhao, Weijia Huang, Jiong Li, Michael J. Donovan, Lina Wang, Juan Ni, Dachi Wang, Ting Fu, Jianguo Feng, Xiaojia Wang, Weihong Tan, Xiaohong Fang*. Nature Communications, 14, 4212, 2023.

•  Hyperbranched Polymer Dots with Strong Absorption and High Fluorescence Quantum Yield for In Vivo NIR-II Imaging. Le Fang, Rui Ai, Wenxi Wang, Lei Tan, Chanyuan Li, Dachi Wang, Ruibin Jiang, Fensheng Qiu, Liqing Qi, Jian Yang, Wei Zhou, Tao Zhu, Weihong Tan, Yifei Jiang*, and Xiaohong Fang*. Nano Letters, 23, 18, 8734-8742, 2023.

• Reprogramming Hypoxic Tumor-associated Macrophages by Nanoglycoclusters for Boosted Cancer Immunotherapy. Yong-Dan Zhao, Hong-Wei An, Muhetaerjiang Mamuti, Xiang-Zhong Zeng, Rui Zheng, Jia Yang, Wei Zhou, Yuxin Liang, Gege Qin, Da-Yong Hou, Xiaolong Liu, Hao Wang*, Yuliang Zhao*, Xiaohong Fang*. Advanced Materials, 2211332, 2023.

Contacts

E-mail:fangxiaohong@him.cas.cn, xfang@iccas.ac.cn

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Hangzhou Institute of Medicine

Chinese Academy of Science

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