Researchers--Hangzhou Institute of Medicine Chinese Academy of Sciences

Biography

Dr. Haibo Wang is a professor in Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences and the deputy director of the Intelligent Molecular Diagnosis Research Center of HIM. She received her BSc in Chemistry from Sun Yat-sen University (with Prof. Zongwan Mao) and PhD in Bioinorganic Chemistry from the University of Hong Kong (with Prof. Hongzhe Sun). Her PhD thesis focused on using metalloproteomics and metallomics approaches to uncover the mode-of-action of metal-based antimicrobial agents. She continued the research in HKU as a postdoctoral fellow on medicinal structure biology from 2018 to 2020. After another two years’ experience of research scientist in University of Zurich, Switzerland, with Prof. Roland K.O. Sigel. She joined HIM as an independent group leader since early of 2023.

Her research group is aiming to integrate wet lab (including chemical biology, structure biology, medicinal chemistry, multi-omics etc) and dry lab (including bioinformatics, virtual screening, molecular modeling and machine learning) to achieve early diagnosis and better treatment of cancer and infectious diseases. Dr. Haibo Wang has published 23 papers in Nature Machine Intelligence, Nature Communications, PNAS, Chemical Science, CCS Chemistry, PloS Biology and Chemical Society Reviews and other top-tier journals. She received many awards, including Overseas Young Talent Scheme in 2023, the special prize CAIA award in 2021, the Best Young Scientist Award etc. Dr. Haibo Wang also served as the guest editor of Frontiers in Chemistry.

Research Interests

1. RNA Molecular Medicine: Analysis of RNA structure and function, targeted intervention and regulation; development of novel RNA-based antiviral and anti-tumor drugs and vaccines.

2. Cancer Diagnosis and Therapy: Identification of tumor biomarkers and microbiomes through multi-omics approaches, and investigation of oncogenic mechanisms.

3. Tumor Metal Immunology: Decoding metal-mediated tumor immune regulation mechanisms and chemical interventions using multi-omics and single-cell mapping; analyzing the function and structure of key metal proteins involved in tumor immune regulation.

4. Nuclear Medicine: Tumor imaging and targeted therapy using radionuclides.

5. AI-Assisted Cancer Prediction and Drug Development: Utilizing artificial intelligence to predict cancer and develop new therapeutic drugs.

Selected Publications

(1) Mitochondrial ATP synthase as the first protein target of chromium(III) in alleviating hyperglycaemia

Haibo Wang#, Ligang Hu#, Hongyan Li#, Yau-Tsz Lai, Xueying Wei, Xiaohan Xu, Zhenkun Cao, Huiming Cao, Qianya Wan, Yuen-Yan Chang, Qunfang Zhou, Guibin Jiang, Aimin Xu, Ming-liang He, Hongzhe Sun* Nature Conmmunications, 2023, 14: 1738.

(2) Dynamic and temporal transcriptomic analysis reveals ferroptosis-mediated anti-leukemia activity of darinaparsin®: insights into novel therapeutic strategy.

Xiaohan Xu,‡Haibo Wang,‡ Hongyan Li, Hongzhe Sun*, CCS Chemistry. 2022, 4: 963–974. (co-first author)

(3) Multi-target mode of action of silver against Staphylococcus aureus endows it with capability to combat antibiotic resistance

Haibo Wang, Minji Wang, Xiaohan Xu, Peng Gao, Zeling Xu, Qi Zhang, Hongyan Li, Aixin Yan, Richard Yi-Tsun Kao, Hongzhe Sun* Nature Communications, 2021, 12,3331.

(4) Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm

Haibo Wang*, Xinming Yang, Minji Wang, Xiaohan Xu, Menglong Hu, Aixin Yan, Quan Hao, Hongyan Li and Hongzhe Sun* Chem. Sci., 2020, 11,11714. (co-corresponding author)

(5) Metalloproteomics in conjunction with other omics for uncovering the mechanism of action of metallodrugs: mechanism-driven new therapy development

Haibo Wang, Ying Zhou, Xiaohan Xu, Hongyan Li and Hongzhe Sun* Curr. Opin. Chem. Biol., 2020, 55, 171-179.

(6) Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli

Haibo Wang, Minji Wang, Xinming Yang, Xiaohan Xu, Quan Hao, Aixin Yan, Menglong Hu, Hongyan Li, Hongzhe Sun* Chem. Sci., 2019, 10, 7193-7199.

(7) Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli

Haibo Wang, Aixin Yan, Zhigang Liu, Xinming Yang, Zeling Xu, Yuchuan Wang, Runming Wang, Mohamad Koohi-Moghadam, Ligang Hu, Wei Xia, Huiru Tang, Yulan Wang, Hongyan Li, Hongzhe Sun* PLoS. Biol., 2019, 17(6): e3000292.

(8) Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach
Mohamad Koohi-Moghadam, Haibo Wang, Yuchuan Wang, Xinming Yang, Hongyan Li, Junwen Wang*and Hongzhe Sun* Nature Machine Intelligence, 2019, 1, 561-567.

(9) Combination of gallium(III) with acetate for combating antibiotic resistant Pseudomonas aeruginosa

Yuchuan Wang#, Bingjie Han#, Yanxuan Xie#, Haibo Wang#, Runming Wang, Wei Xia, Hongyan Li, Hongzhe Sun* Chem. Sci., 2019. 10, 6099-6106.(co-first author)

(10) Binding of ruthenium and osmium at non-iron sites of transferrin accounts for their iron-independent cellular uptake

Minji Wang#, Haibo Wang#, Tsz-Pui Lai, Ying Zhou, Ailun Chao, Quan Hao, Hongyan Li, and Hongzhe Sun* J. Inorg. Biochem., 2022, 234, 111885.(co-first author)