Biography

Dr. Xiangsheng Liu is a professor and the director of Innovative Drug Research Center at Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences. He is a doctoral supervisor and recipient of the National Natural Science Fund for Excellent Young Scientist Fund Program (Overseas). Dr. Liu received his B.S. degree and Ph.D. degree from Zhejiang University in 2009 and 2014, respectively. He was a postdoctoral associate at UCLA during 2014 to 2019. He became the project scientist at UCLA in 2019, and then moved to HIM in October 2020. He is the recipient of National Key Research and Development Program, the National Natural Science Foundation of China, and the Zhejiang Provincial Natural Science Foundation. Dr. Liu has authored over 90 publications with more than 5,000 citations, including over 30 papers published as the first or corresponding author in high-impact journals such as Journal of Clinical Investigation (JCI), ACS Nano, Advanced Science, Nature Communications and Matter.

Research Interests

Dr. Liu’s Lab is interested in the areas: Aptamer-drug conjugates (ApDC), mRNA drugs and vaccines, nanomedicine, nano-biological interface effects, etc. Dr. Liu’s Lab aims to provide safer and more effective prevention and treatment methods for cancer and other serious diseases.

Selected Publications

1. Dong, S. #; Feng, Z. #; Ma, R.; Zhang, T.; Jiang, J.; Li, Y.; Zhang, Y.; Li, S.; Liu, X.; Liu, X.*; Meng, H*. Engineered Design of a Mesoporous Silica Nanoparticle-Based Nanocarrier for Efficient mRNA Delivery in Vivo. Nano Letters 2023, 23, 2137-2147.

2. Liu, X. #; Xie, X. #; Jiang, J. #; Lin, M.; Zheng, E.; Qiu, W.; Yeung, I.; Zhu, M.; Li, Q.; Xia, T.; Meng, H.* Use of Nanoformulation to Target Macrophages for Disease Treatment. Advanced Functional Materials2021, 31, 2104487.

3. Liu, X.; Jiang, J.; Chang, C. H.; Liao, Y. P.; Lodico, J. J.; Tang, I.; Zheng, E.; Qiu, W.; Lin, M.; Wang, X.; Ji, Y.; Mei, K. C.; Nel, A. E.* and Meng, H*. Development of Facile and Versatile Platinum Drug Delivering Silicasome Nanocarriers for Efficient Pancreatic Cancer Chemo-Immunotherapy. Small2021, e2005993.

4. Liu, X.; Jiang, J.; Liao, Y-P.; Tang, I.; Zheng, E.; Qiu, W.; Lin, M.; Wang, X.; Ji, Y.; Mei, K-C.; Liu, Q.; Chang, C. H.; Wainberg, Z. A.; Nel, A. E. * and Meng, H*, Combination Chemo‐Immunotherapy for Pancreatic Cancer Using the Immunogenic Effects of an Irinotecan Silicasome Nanocarrier Plus Anti-PD-1, Advanced Science2021, 8, 2002147.

5. Ji, Y. #; Liu, X. #; Li, J.; Xie, X.; Huang, M.; Jiang, J.; Liao, Y-P.; Donahue, T.; Meng, H. *, Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment, Nature Communications 2020, 4249.

6. Liu, X.#; Jiang, J.#; Chan, R.; Ji, Y.; Lu, J.; Liao, Y-P.; Okene, M.; Lin, J.; Lin, P.; Chang, C.H.; Wang, X.; Tang, I.; Zheng, E.; Qiu, W.; Wainberg, Z. A.; Nel, A. E.*; Meng, H.*, Improved Efficacy and Reduced Toxicity Using a Custom-Designed Irinotecan-Delivering Silicasome for Orthotopic Colon Cancer. ACS Nano2019, 13, 38-53.

7.. Liu, X.; Lin, P.; Perrett, I.; Lin, J.; Liao, Y.-P.; Chang, C. H.; Jiang, J.; Wu, N.; Donahue, T.; Wainberg, Z.; Nel, A. E.*; Meng, H.*, Tumor-penetrating peptide enhances transcytosis of silicasome-based chemotherapy for pancreatic cancer. Journal of Clinical Investigation 2017, 127, 2007–2018.

8. Liu, X.; Situ, A.; Kang, Y.; Villabroza, K. R.; Liao, Y.-P.; Chang, C. H.; Donahue, T.; Nel, A. E.*; Meng, H.*, Irinotecan delivery by lipid-coated mesoporous silica nanoparticles show improved efficacy and safety over liposomes for pancreatic cancer. ACS Nano 2016, 10, 2702–2715.

9. Liu, X.; Chen, Y.; Li, H.; Huang, N.; Jin, Q.; Ren, K.; Ji, J.*, Enhanced retention and cellular uptake of nanoparticles in tumor by controlling their aggregation behavior. ACS Nano2013, 7, 6244-6257.

10. Liu, X.; Cao, J. M.; Li, H.; Li, J. Y.; Jin, Q.; Ren, K. F.; Ji, J.*, Mussel-inspired polydopamine: a biocompatible and ultrastable coating for nanoparticles in vivo. ACS Nano2013, 7, 9384-9395.

Contacts

E-mail: liuxs@him.cas.cn

Office Room: 4-304

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000