Biography

Dr. Fengli Qu obtained her Ph.D. of analytical chemistry under the supervision of Prof. Ruqing Yu from Hunan University in 2008. From 2008 to 2009, she engaged in postdoctoral research at Centre National de la Recherche Scientifique in France. Concurrently, she joined the College of Chemistry and Chemical Engineering at Qufu Normal University as an associate professor in 2008. From 2013 to 2014, she served as a visiting professor at Princeton University in America. From 2019 to 2020, she held the position of mobility establishment project director at the National Natural Science Foundation of China (NSFC). In 2020, she moved to Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences as a research fellow. She was selected into the 2019 Young Scholars of Chang Jiang Scholars Program and the 2019 Young Scholars of Shandong Taishan scholars Program.

Research Interests

Her research interests encompass intelligent biosensing and molecular diagnosis in the cross field of analytical chemistry and life sciences. Specialized research directions are presented as follows:

1)     Nucleic acid-mediated nano-biosensing interfaces construction

2)     Disease-related biomarkers detection and analysis

3)     Advancement of liquid biopsy technology in cancer diagnosis and prognosis

4)     Exosome analysis and diagnostic/therapeutic applications

Selected Publications

1. Jin Li, Yingying Li, Qin Li, Lu Sun, Qingqing Tan, Liyan Zheng, Ye Lu, Jianqing Zhu, Fengli Qu*, Weihong Tan*. An Aptamer-Based Nanoflow Cytometry Method for the Molecular Detection and Classification of Ovarian Cancers through Profiling of Tumor Markers on Small Extracellular Vesicles. Angew. Chem. Int. Ed., 2024, 63(4):e202314262.

2. Weidi Sun, Hui Zhang, Wanlin Xie, Lele Ma, Yang Dang, Yuan Liu, Ling Li, Fengli Qu*, Weihong Tan*. Development of Integrin-facilitated Bispecific Aptamer Chimeras for Membrane Protein Degradation. J. Am. Chem. Soc., 2024. (Accepted)

3. Lingyu Nie, Hui Zhang, Weiheng Kong, Rong-Mei Kong, En-Sheng Zhang, Jin Li, Yan Zhao*, Fengli Qu*. Integrating a Copper-Histidine Brace in a Mimetic Nanozyme Streamlines the Tyrosinase Recognition Moiety to Achieve Chiral Differentiation. Anal. Chem., 2024. 10.1021/acs.analchem.4c01966.

4. He Li, Jingchen Zhang, Huaijiang Li, Ensheng Zhang, Weiheng Kong, Rong-Mei Kong, Yan Zhao*, Fengli Qu*, Weihong Tan. Twisted intramolecular charge transfer-basedviscosity-responsive probe reveals lysosomaldegradation process of endocytosed foreignbodies. Anal. Chem., 2024.

5. Liyan Zheng, Jin Li, Yingying Li, Weidi Sun, LeLe Ma, Fengli Qu*, Weihong Tan*. Empowering Exosomes with Aptamers for Precision Theranostics. Small Methods. 2024:e2400551.

6. Sitao Xie, Weidi Sun, Ting Fu, Xiangsheng Liu, Peng Chen, Liping Qiu, Fengli Qu*, Weihong Tan*. Aptamer-Based Targeted Delivery of Functional Nucleic Acids. J. Am. Chem. Soc., 2023, 14, 7677-7691.

7. Yan Zhao, Xinquan Yu, Weiheng Kong, Rong-mei Kong, Ensheng Zhang, Lian Xia, Jing Zhang, Fengli Qu* and Weihong Tan. Responsive calcium-derived nanoassemblies induce mitochondrial disorder to promote tumor calcification. Chem. Sci. 2023, 14, 9350-9359.

8. Yan Zhao, Xinquan Yu, Xiao Liu, Dailiang Zhang, He Li, Hanlin Zhou, Weiheng Kong, and Fengli Qu*. ClO- Induced Dual-Excitation Fluorescent Probes Responding to Diverse Testing Modes with Ratio Methodology, Anal. Chem., 2023, 95, 7170-7177.

9. Dailiang Zhang, Ruizi Peng, Wenfei Liu, Michael J. Donovan, Linlin Wang, Ismail Ismail, Jin Li, Juan Li, Fengli Qu*, Weihong Tan*, Engineering DNA on the surface of upconversion nanoparticles for bioanalysis and therapeutics, ACS Nano, 2021, 15, 17257-17274.

10. Xiankang Niu, Changtong Lu, Dan Su, Fang Wang, Weihong Tan, Fengli Qu*, Construction of a polarity-switchable photoelectrochemical biosensor for ultra-sensitive detection of miRNA-141, Anal. Chem., 2021, 93, 13727-13733.

11. Xiuli Wang, Abudurexiti Rehman, Rong-Mei Kong,Yuanyuan Cheng, Xiaoxia Tian, Maosheng Liang, Lingdong Zhang, Lian Xia,* Fengli Qu*, Naphthalimide derivative-functionalized metal-organic framework for highly sensitive and selective determination of aldehyde by space confinement-induced sensitivity enhancement effect, Anal. Chem., 2021, 93, 8219−8227.

12. Xiankang Niu, Yan Zhao, Fang Wang, Jinghua Wu, Fengli Qu*, Weihong Tan, Ultrasensitive Photoelectrochemical Biosensor Based on Novel Z-Scheme Heterojunction of Zn-Defective CdS/ZnS for MicroRNA Assay, Anal. Chem., 2021,93(51):17134-17140.

13. Lan Guo, Maosheng Liang, Xiuli Wang, Rongmei Kong, Guang Chen, Lian Xia*, Fengli Qu*, The tongs role of L-histidine: a strategy of grasping Tb3+ by ZIF-8 to design sensors for monitoring anthrax biomarker on-the-spot, Chem. Sci., 2020, 11, 2407-2413.

Contacts

E-mail: qufengli@him.cas.cn

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310000