Biography

Dr. Hao Chang obtained his Ph.D. from Zhejiang University in 2015 and subsequently worked as a Research Fellow at Nanyang Technological University (Singapore) and City University of Hong Kong from 2016. In June 2021, he joined the Hangzhou Institute of Medicine, Chinese Academy of Sciences, as a Researcher and Principal Investigator. His research focuses on the development and biomedical applications of innovative microneedle-based diagnostic and therapeutic devices. Dr. Chang has authored over 50 publications in leading journals, including Nature Biomedical Engineering, Advanced Materials, Biomaterials, Chemical Engineering Journal, Small, and Journal of Controlled Release. He holds 11 patents, among which 3 U.S. and 3 Chinese patents have been granted. His awards include the National Natural Science Foundation of China (NSFC) Young Scientists Fund (Category B, formerly Excellent Young Scientists Fund), the CAS Hundred Talents Program, and the Zhejiang Provincial Excellent Young Scientists Fund. He has also received the Wiley China Outstanding Author Award, Wiley China High Contribution to Open Science Award, and the Silver Medal at the Geneva International Exhibition of Inventions.

Research Interests

His research interests include biomaterials, drug delivery, micro-/nanotechnologies, regenerative medicine, biomedical engineering. Currently, his research focuses on engineering advanced microneedle-based drug delivery systems and biosampling devices for diverse biomedical applications, such as vaccination, tumor immunotherapies, cell therapies and point-of-care diagnosis, et al.

Selected Publications

1. Z. Li, X. Wen, S. Lu, Y. Zheng, P. Zhao, S. Mu, X. Wang, Y. Shi, F. Qu, H. Chang*, Ice-pop making inspired photothermal ultra-swelling microneedles to facilitate loading and intradermal vaccination of tumor antigen, Journal of Controlled Release 2025, 379: 77-88

2. Z. Ma, Y. Li, J. Zhu, S. Qiu, Y. Chen, H. Cao, S. Yang, X. Jia, L. Huo, Q. Shi, S. Han*, H. Chang*, X. Yu*, Bone marrow-targeted thrombopoietin delivery via engineered platelet-derived vesicle-loaded dissolving microneedles for treating ionizing radiation-induced injury, Materials Today Bio 2025, 33: 101980

3. P. Zhao, T. Liu, Y. Shi, Z. Li, S. Lu, F. Jia, H. Chang, Intradermal implantation of methotrexate-loaded puerarin-gelatin hydrogel via bubble-generating microneedles for psoriasis treatment, International Journal of Biological Macromolecules 2025, 284(Pt 2): 138201.

4. S. Lu, Z. Li, Y. Shi, X. Wang, H. Chang*, Efficient extraction of interstitial fluid using an ultrasonic-powered replaceable hexagram-shaped hydrogel microneedle patch for monitoring of dermal pharmacokinetics and psoriatic biomarkers, Chemical Engineering Journal 2024, 500: 157293

5. S. Mu, T. Qian, Z. Li, P. Zhao, Y. Tao, H. Chang*, F. Qu*, Long-term storage and intradermal vaccination of tumor-derived exosomes via sugar microneedles for improving tumor immunotherapies, Chemical Engineering Journal 2024, 497: 155595

6. Y. Zheng, Z. Li, S. Li, P. Zhao, X. Wang, S. Lu, Y. Shi, H. Chang*, Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses, Acta Biomaterialia 2024, 185: 203-214.

7. Z. Ling, Y. Zheng, Z. Li, P. Zhao, H. Chang*, Self-healing porous microneedles fabricated via cryogenic micromoulding and phase separation for efficient loading and sustained delivery of diverse therapeutics, Small 2024, 20(16): e2307523.

8. Z. Li, P. Zhao, Z. Ling, Y. Zheng, F. Qu, H. Chang*, An ultraswelling microneedle device for facile and efficient drug loading and transdermal delivery, Advanced Healthcare Materials 2024, 13(2): e2302406.

9. H. Chang, S.W.T. Chew, M. Zheng, D.C.S. Lio, C. Wiraja, Y. Mei, X. Ning, M. Cui, A. Than, P. Shi, D. Wang, K. Pu, P. Chen, H. Liu, C. Xu*, Cryomicroneedles for transdermal cell delivery, Nature Biomedical Engineering 2021, 5(9): 1008-1018.

10. H. Chang, M. Zheng, X. Yu, A. Than, R.Z. Seeni, R. Kang, J. Tian, D.P. Khanh, L. Liu, P. Chen*, C. Xu*, A swellable microneedle patch to rapidly extract skin interstitial fluid for timely metabolic analysis, Advanced Materials, 2017, 29(37): 1702243

Contacts

E-mail: changhao@him.cas.cn

Website: https://scholar.google.com/citations?user=O4t517gAAAAJ&hl=en

Office Room: 1-806 (Heda Pharmaceutical Valley Stage 4)

Hangzhou Institute of Medicine

Chinese Academy of Science

150 Fucheng Road, Qiantang District

Hangzhou, Zhejiang Province, China 310018